Histology of vaccine myocarditis; PFO closure for divers; New Evolut OK valve


Young people with low levels of physical activity were found to have an increased risk of stroke if they presented 8 hours or more of sedentary time per day. (Stroke)

Mavacamten priced at $ 75,000 per year would be less profitable than myectomy and septal ablation for hypertrophic cardiomyopathy patients, found a draft ICER report.

In vaccine-induced immune thrombotic thrombocytopenia associated with AstraZeneca COVID-19 vaccine, thrombus formation is accompanied by activation of neutrophils and various immune pathways. (European Heart Journal)

Two cases of histologically confirmed myocarditis after COVID mRNA vaccination: one on endomyocardial biopsy and the other on autopsy. (New England Journal of Medicine)

The American Heart Association (AHA) called for more research on identify and manage opioid use disorders in people with cardiovascular disease. (Circulation)

About 1% to 6% of children and adolescents have obstructive sleep apnea. Whether this condition alone predisposes them to hypertension remains to be seen, the AHA said. (Journal of the American Heart Association)

Registry data showed that outpatient prescribing practices for PCSK9 inhibitors very varied according to breed, geography and practice across the United States through 2019. (Circulation: cardiovascular quality and results)

Seniors with heart failure have seen quality of life benefits left ventricular assist devices, suggested INTERMACS registry data. (Journal of the American College of Cardiology)

Composition of intestinal bacteria plays a role in the relationship between foods rich in flavonoids (eg, fruits, vegetables, tea, chocolate, red wine) and low blood pressure. (Hypertension)

Patients with a low burden of paroxysmal atrial fibrillation may see this burden further reduced within one year of catheter ablation, as well as an improvement in the quality of life, according to a secondary analysis of CIRCA-DOSE. (JAMA Cardiology)

Divers who received patented foramen ovale closure had no incidents decompression sickness over the next 6.5 years on average. (JACC: Cardiovascular Imaging)

Remote ischemic conditioning, proposed in blood pressure cuff inflation cycles, has been rejected as a means of reducing reperfusion injury during primary percutaneous coronary intervention for MI with ST-segment elevation. (Heart)

A rare case of late clinical leaflet thrombosis occurred 1.5 years after catheter aortic valve replacement (TAVR) despite treatment with clopidogrel (Plavix) and edoxaban (Savaysa). (JACC: Case reports)

The FDA has approved the Fourth Generation Evolut FX from Medtronic’s line of TAVR systems. This device received gold marks for direct viewing, a redesigned catheter tip and a more flexible delivery system, Medtronic said.

Janssen announced that rivaroxaban (Xarelto) now has an expanded FDA indication for patients with peripheral artery disease fresh from lower limb revascularization.

The agency also cleared the CardioNXT iMap 3D mapping system for use in patients with cardiac arrhythmias, the manufacturer said.

An algorithm based on remote monitoring data was able to predict two-thirds of post-implant hospitalizations for heart failure, announced Biotronik.

A selective serotonin reuptake inhibitor outperformed exercise for the treatment of anxiety in patients with coronary artery disease, a small randomized trial showed. (JAMA Psychiatry)

Immigrants to Canada had a 33% lower stroke rate as long-term residents. (Neurology)

Can the antiplatelet agent sarpogrelate (Anplag) stop cardiac hypertrophy in his footsteps? The AHA highlights a mouse study that suggests it.

  • Nicole Lou is a reporter for MedPage Today, where she covers current events in cardiology and other developments in medicine. To follow

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